Star Files Abby Mueller Related Shows from $79.00 Don’t lose your head, Anne Boleyn (a.k.a. Andrea Macasaet)! Brittney Mack, Abby Mueller and the cast of “Six.” (Graphics by Ryan Casey for Broadway.com) “It’s another exciting day in the queendom,” says Six star Abby Mueller in the second episode of her vlog Yas, Queen. Mueller gives viewers a backstage look at a busy day in the life of a Six queen, which includes fittings, a press junket, rehearsals and getting pink goo squeezed into your ear. (“It felt like it was poking my brain.”) Cast members also talked about their favorite things about New York City; the answers ranged from chicken nuggets at Shake Shack to the city’s cultural “melting pot.” Co-creator and co-director Lucy Moss also reacted to the news that at 26, she’s the youngest female director to ever work on Broadway: “It’s actually fun—and actually depressing—but fun for me!” Watch the rest of the vlog below, and take some of these gifs with you for your moods.Look who’s on a Times Square billboard! Six Watch the full vlog below! Video Player is loading.Play VideoPlayMuteCurrent Time 0:00/Duration 11:28Loaded: 0.00%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -11:28 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedEnglishAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button. View All (6) Anna Uzele Andrea Macasaet View Comments Brittney Mack Samantha Pauly Adrianna Hicks
Republican Ballot Newt Gingrich 4,937 8.1% Jon Huntsman 1,195 2.0% Ron Paul 15,343 25.3% Rick Perry 543 0.9% Mitt Romney 23,955 39.5% Rick Santorum 14,345 23.6% The Canvassing Committee members signed a Certificate of Greatest Number of Votes for Barack Obama in the Democratic Primary. The Canvassing Committee members signed a Certificate of Greatest Number of Votes for Mitt Romney in the Republican Primary. The certificates recited that it is the understanding of the Canvassing Committee members that delegates to the Democratic and Republican National Conventions will be bound according to party rules. The Democratic National Primary is scheduled for September 4-6. The Republican National Convention is scheduled for August 27-30. Source: Vermont Secretary of State. 3.13.2012 Secretary of State Jim Condos chaired the statewide canvassing committee for the Presidential Democratic and Republican Parties at 128 State Street, Montpelier, on Tuesday and released the official presidential primary results. Secretary Condos provided copies of the Official Report of the Canvassing Committee for the Presidential Primary Election for the Republican and Democratic candidates. The results are provided on a town by county basis for the Presidential Primary. The statewide canvassing committee membership is set by state law as the chair of each major party, or his or her designee, and the Secretary of State. In attendance this morning were Jim Condos, Secretary of State; Jake Perkinson, Democratic Party Chair; Morgan Daybell, designee for Martha Abbot, Progressive Party Chair; and Marty Searight, designee for Jack Lindley, Republican Party Chair. The total votes counted in both parties for the president was 103,264 for a 23% voter turnout. There were 41,519 votes cast in the Democratic Primary with 40,156 votes for Barack Obama. There were 61,537 votes cast in the Republican Primary with 23,955 (39.5%) votes for Mitt Romney. Democratic Ballot Barack Obama 40,156 98.4%
Despite impressive growth in TriStar events across Europe, and support from elite triathlete Chris McCormack in recent marketing, the TriStar111 Lisboa event has sadly been cancelled.According to Georg Hochegger, CEO of Star Production SARL, the Monaco-based headquarters for the new TriStar Series, “Too many obstacles in finding agreements with the local organiser led to the decision that the TriStar111 Lisboa should not take place. The event has thus been cancelled. While the local organisers in Lisboa wish to take the step back to the initial format, Star Production concentrates on other destinations like TriStar222 Sardinia taking place in October.”The TriStar111 Lisboa event was originally intended to take place on 24 April 2010. As with other TriStar events, a new distance concept was on offer: 1K swim, 100K bike and 10K run. In addition to TriStar111, Star Production has introduced a TriStar222 double distance format: 2K swim, 200K bike and 20K run. The TriStar 200 format offers varying combinations of the three disciplines.Ironman 70.3 Austria winner, and 4th placed male at the Ironman World Championships in Kona in 2009, Chris McCormack is quoted in ads placed by Star Production. McCormack noted that “People are looking for challenges that are tough, in places that are unique and different and fun. The new brand Star Events offers another option for athletes.”Olivier Castelli, Global Event Operation Director of Star Production, gave further background to the decision to pull TriStar111 Lisboa. “Maybe our important inputs to improve the race — an entirely new finish line area for example — will be put into practice for the Lisboa International Triathlon although it will not be run as part of the TriStar series. Of course this means a non TriStar event profits from our experience, and at the same time we are okay to look at it like development aid, if it makes a race better for athletes. Triathlon should be fun, whatever the brand,” he said.Now that TriStar111 Lisboa is cancelled, athletes can either transfer their entry to another race or be refunded the entire entry fee. For transfers to other TriStar races, athletes can contact email@example.com.Star Production SARL is the Monaco-based organiser of the new TriStar series. The first event took place in September 2009 in Andaluc Related
Gophers seek improvement against nonconference foesMinnesota welcomes West Virginia, Nebraska and New Mexico State to the Metrodome for the annual Dairy Queen Classic. Samuel GordonMarch 1, 2012Jump to CommentsShare on FacebookShare on TwitterShare via EmailPrintMajor League Baseball teams have 20-30 spring training games to make improvements, finalize the roster and prepare for the rigorous regular season.The Gophers have zero.“Unfortunately, we don’t have spring training,” Minnesota head coach John Anderson said. “The [early season] games count but at the same time, you’re trying to learn about your team.”The Gophers (3-4) will get a chance for some more self-discovery this weekend when they welcome Nebraska (4-3), West Virginia (3-4) and New Mexico State (7-3) to the Metrodome for the Dairy Queen Classic.The four-team tournament is now in its 28th year and is back in Minneapolis after taking place in Arizona a year ago.Minnesota has learned one thing early on — it will need to score more runs if it wants to stay competitive.The Gophers scored eight runs in four games last weekend and although their starting pitching was formidable, it’s tough to win consistently without more scoring.Minnesota put only one run on the board in three of four games against Wisconsin-Milwaukee and struck out 30 times collectively.“We obviously know that we have a good pitching staff and that we can play defense,” second baseman Matt Puhl said.“Hitting is going to be key for us. We need to put up five, six runs a game, put some quality at-bats together and definitely limit the strikeouts.” Minnesota ace TJ Oakes acknowledged that pitching without any run support adds pressure to the starters but said he doesn’t worry about it too much.“You’ve just got to pitch your game and trust that the offense will get some runs along the way,” he said.Anderson, who’s in his 31st year at the helm, said it generally takes 20 to 25 games to get a true sense of a player’s ability.“That’s why [the pros] have spring training. That’s what it’s about, trying to get your team ready for the season,” he said. “You’re trying to learn about them. They’re trying to learn about themselves. You’re trying to make adjustments.”There are just two senior position players on the roster this year — outfielder Trip Schultz and third baseman Kyle Geason — and the team’s inexperience is evident thus far.How the young players mature will ultimately determine how successful the club can be, Anderson said.“They’re going to have to learn to handle their stress and learn to be comfortable in the game environment and in the practice environment,” he said. “That’s why it takes 20 to 25 games to get settled in.”The Gophers will get a sneak-peak at Big Ten foe Nebraska this weekend, which could be advantageous come conference play.“We’ll probably see them all three times here. We’ll get a good scouting report on their hitters and a good scouting report on all three of their pitchers,” Oakes said. “We should be prepared for them next time when we head to Nebraska at the end of the year.”
“I’ve been working on my footwork a lot in practice, just making sure if I mess up in the game I can just go back to the process. Make sure I know, I need to get my third step there or put my fourth step down,” she said. “Just those things have been helping me in my performance I think.” To her teammates, her strong performances in the tournament are no surprise. “She’s been awesome and she’s really helped to carry our team offensively especially,” libero C.C. McGraw said. Rollins and McGraw have been stellar to this point in the tournament, but now find themselves in unfamiliar territory: the Final Four. They will, however, see a familiar opponent in No. 3 Stanford. The Gophers met Stanford in Minnesota’s sixth match of the year, a match the Gophers took 3-1 and was the third of a 10-match winning streak. McGraw and Rollins had 20 and 15 digs respectively in that match. It may be a different Stanford team than Minnesota saw in that early season matchup, but the Gophers are ready to take on the defending national champions, an improvement from last season when they watched Stanford win it all in Minneapolis.“I went to the semifinals, I saw both. I think it was a good experience to go watch because that’s my dream to go play. A year ago watching, I was like, ‘Man I really want to be there,’” Rollins said. “Now we’re here and it’s awesome. I think it was a good experience to see that and see how these teams got there.” “It was good motivation. I even took a picture of the court and look at it here and there.” Adanna Rollins leading rejuvenated Gophers offense to Final FourEyeing its first national championship, Minnesota will need to get past defending national champion Stanford on Thursday.Sydni RoseOutside hitter Adanna Rollins spikes the ball during the game against the Fairfield Stags in the first round of the NCAA tournament at the Maturi Pavilion on Friday, Dec. 6. Nolan O’HaraDecember 19, 2019Jump to CommentsShare on FacebookShare on TwitterShare via EmailPrintComing off their grueling five-set win over Creighton, Gophers volleyball head coach Hugh McCutcheon stressed the need for offensive production. In that win, the Gophers hit .141, a large drop off from the .434 hit percentage they posted the night before. Regardless, Minnesota secured the win. Conversely, the Gophers have ranked towards the top of the Big Ten defensively all season long. First in blocks, and digs and second in opposing hit percentage, Minnesota’s effort on defense kept its season alive when when its offense sputtered against the Bluejays. Escaping with the win, the Gophers turned their attention to a familiar opponent, No. 10 Florida, knowing they wouldn’t be playing much longer if the offense continued to lag behind. They answered McCutcheon’s call, posting a .331 hit percentage in the five-set victory. When the fifth set came to a close, four Gophers had double-digit kills including outside hitter Adanna Rollins, who has led the way for Minnesota offensively and helped the offense get back on track.She leads the team with 55 kills in the NCAA Tournament and also has 32 digs over that stretch. After their win over Louisville, in which Rollins led the team with 12 kills and was one dig shy of a double-double, she was named the most outstanding player of the Austin Region All-Tournament Team. McCutcheon called her performance “big time.” “Not many people understand the weight you have to carry as a six rotation outside,” he said. “I gave her a hug afterwards, told her I was proud of her because I am. I think she’s come through a lot. She did a great job.”In practice, Rollins has been working on her footwork, something she’s said has been “choppy at times,” but certainly hasn’t been throughout the tournament.
Today two studies describe the prevalence and scope of Zika infection in mosquito species in Brazil and Mexico, with one study suggesting the virus was in Rio as early as 2012, 2 years before human cases.Evidence for 2012 virus presenceA study published yesterday in Emerging Infectious Diseases describes deep gene sequencing performed on more than 400 Aedes aegypti mosquitoes captured in the Manguinhos neighborhood in Rio de Janeiro during the height of the Zika outbreak, from February 2014 to June 2016.The results of the genetic analysis suggest the insects were infected with the virus at least 2 years before the first human case appeared in the city.”We showed the presence of Zika virus in engorged Ae. aegypti mosquitoes trapped in Rio de Janeiro before the first case of autochthonous Zika virus disease was diagnosed in the city,” the authors said. “This finding emphasizes the importance and benefit of routine entomologic surveillance programs to public health in terms of ensuring timely implementation of disease prevention and control measures.”Five mosquito species show evidence of ZikaIn related news, a study published yesterday on the pre-publication server bioRxiv shows that five different mosquito species—Ae aegypti, Ae vexans, Culex quinquefasciatus, C coronator, and C tarsalis—contained Zika virus in their salivary glands.Mexican researchers collected the insects in Mexico, and the findings suggest that each species is capable of Zika transmission.The mosquitoes were collected over 5 days in Guadalajara in November 2016. A total of 579 mosquitoes were evaluated for the presence of the Zika virus.Olympics risk, Zika in infants, Texas casesAnother brief study in Emerging Infectious Diseases showed that 17 out of 21 tested members of Spain’s Olympic team were negative for the Zika virus after the 2016 Games in Rio de Janeiro despite having symptoms, suggesting there was limited risk of transmission. Blood tests were conducted in Spain 20 and 30 days after the Olympics.Four athletes had false-positive results, while 17 tested negative. All had received counseling before the Games on Zika transmission, including on safe sex practices.Elsewhere, the National Institute of Allergy and Infectious Diseases (NIAID) will be conducting field tests in Guatemala to determine if the Zika virus can attack infants’ brains, the agency said in a press release yesterday from the National Institutes of Health (NIH), which oversees the NIAID. Zika is still widely circulating in Guatemala.The study will look at children 3 months and younger to determine what if any impact early Zika infection has on developing brains. The NIAID hopes to have preliminary results available in a year.”This natural history study of Zika among Guatemalan children promises to yield valuable insights into acute and longer-term outcomes of infection,” said NIAID Director Anthony S. Fauci, MD. “It is imperative that we understand the potential neurologic and neurodevelopmental outcomes of Zika virus infection in children infected in infancy and early childhood.”Finally, a Texas health group has retracted an earlier report that said there were six new cases of Zika in the Houston area, the Houston Press reported yesterday.On Jun 15, representatives from Legacy Health Group in Houston said six pregnant women had tested positive for the disease. The claim was not corroborated by the US Centers for Disease Control and Prevention, and Legacy has apologized for the error.See also:Jun 19 Emerg Infect Dis early evidence studyJun 19 bioRxiv studyJun 19 Emerg Infect Dis Spain studyJun 19 NIH news releaseJun 19 Houston Press story
Platform uses metabolomic analysis to uncover novel antibioticsA study today in Science Translational Medicine describes a new approach to determining the modes of action underlying antimicrobial compounds that could help speed the process of discovering novel antibiotics.The platform developed by a team of European scientists involves rapid systematic metabolome profiling, a process that uses mass spectrometry to analyze and measure the changes that occur in metabolites—the small molecules produced by bacteria—upon treatment with a drug or compound. The idea is that these changes will provide clues to the underlying modes of action.To test this strategy, the team exposed Mycobacterium smegmatis to multiple doses of 62 reference compounds with known modes of action, including currently used antibiotics and chemical stress agents, and used a computational framework to parse out predicted modes of action based on pairwise comparisons between known chemicals. They then tried this approach on 212 uncharacterized compounds from a drug discovery program by pharmaceutical company GlaxoSmithKline. This revealed 16 compounds that appeared to target unconventional cellular processes, and 6 with potentially new modes of action that exerted anti-tuberculosis effects by targeting fatty acid metabolism.The authors of the study say the advantage of their approach for predicting modes of action in chemical screens is that it discriminates between compounds with previously known modes of action and those with new modes of action. “Knowing the MoAs [modes of action] of compounds at an early stage of drug discovery can guide the selection of the most promising leads, even in cases where the drugs do not yet exhibit strong bactericidal or bacteriostatic effects,” they write.Feb 21 Sci Transl Med studyCDC launches online antibiotic stewardship courseThe US Centers for Disease Control and Prevention (CDC) yesterday launched a new online antibiotic stewardship course.The interactive web-based activity is designed to help clinicians optimize antibiotic use to combat antibiotic resistance and improve healthcare quality and patient safety. The course will provide an overview of antibiotic resistance and explain the benefits of antibiotic stewardship across the healthcare spectrum. It will also discuss the risks and benefits of antibiotics, with a specific focus on the microbiome, adverse drug events, and Clostridium difficile infections. The first module will focus on outpatient antibiotic stewardship, and the following modules will focus on stewardship in acute care hospitals and long-term care facilities.The CDC says the goal of the course is to help healthcare professionals deliver effective and consistent message about antibiotic use and antibiotic resistance to patients, and to provide guidance for how to apply antibiotic stewardship principles to the most common conditions that lead to inappropriate use. Feb 20 CDC training on antibiotic stewardship Infection diagnostic codes tied to higher rates of previous antibioticsChicago researchers who analyzed data on 78,094 patients found that diagnostic codes for infections are strong surrogate markers for prior antibacterial exposure, especially to broad-spectrum antibiotics, which may help identify patients who harbor multidrug-resistant bacteria.Writing in Infection Control & Hospital Epidemiology, the investigators, from Cook County Health and Hospital System in Chicago detailed findings from 121,916 hospitalizations involving 78,094 patients in three Chicago-area hospitals.Of the 121,916 inpatient encounters, 24% had an associated infection code, 47% of patients received an antibacterial drug, and 13% received a broad-spectrum antibacterial. Patients with infection-related ICD-9-CM codes had more than twice the rate of antibacterial use compared with those lacking such codes (relative risk [RR], 2.29) and a fivefold increased risk for broad-spectrum antibacterial use (RR, 5.52). CD-9-CM codes were also linked to a tripling of the number of antibacterial days.The authors concluded, “Such an association can be used to enhance early identification of patients at risk of multidrug-resistant organism (MDRO) carriage at the time of admission.”Feb 20 Infect Control Hosp Epidemiol abstract
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Allegations that a bullying lord chancellor acted improperly in his dealings with the Law Society over criminal legal aid reforms were rebutted by his barrister today.In the second day of a case brought by the Criminal Law Solicitors’ Association and the London Criminal Courts Solicitors’ Association – and part-funded by the Law Society – James Eadie QC said there was ‘no impropriety’ in the way Chris Grayling had acted.The two groups challenge the lawfulness of a consultation on the reforms because of the government’s failure to publish and consult on consultants’ reports.Mr Justice Burnett heard yesterday that Grayling (pictured) had become personally involved in the consultation process and misled the Law Society by threatening it with the introduction of price-competitive tendering (PCT). The claimants alleged that when the Ministry of Justice reached an agreement with the Society in August 2013 on the introduction of a new dual-contracting regime, it had already decided to abandon PCT. But Eadie told the court today that at the August meeting with the Law Society, PCT was still on the table as an option. He said the ‘serious allegations’ made against Grayling had ‘no evidential basis’ and caused a ‘certain amount of umbrage’ among ministry officials.Burnett invited Jason Coppel QC, for the claimants, to withdraw the ‘unattractive submission’ that Grayling had personally lied in his dealings with the Law Society, which he said was without evidence and ‘of no relevance’ to the decision he had to make.Coppel replied that he had not told the court that Grayling had lied.Putting the lord chancellor’s case in response to the judicial review application, Eadie said there had been ‘prolonged and intensive engagement’ with the profession and its representative bodies, including the Law Society and the two claimant groups.The skeleton argument said the ‘lengthy, multi-stage’ consultation process that began in summer 2012 also included two consultation papers and a series of public meetings attended by thousands of practitioners.Eadie said under the public law principles on the duty to consult it is a matter for the executive to decide how it informs itself on policy decisions – who it consults and on what information.He said the claimants and profession were well aware, during the consultation process and before the publication of the reports, of the factors and criteria that would be considered by the lord chancellor in determining the number of contracts to be made available.The four criteria, he said – sufficient supply; sufficient case volume; market agility; and sustainable procurement – were identified in both consultation papers, and comments invited upon them.The issues considered by the two undisclosed documents – the Otterburn report on the financial state of firms and the KPMG contract modelling report – were precisely those which the claimants knew the lord chancellor was considering. Re-opening the consultation, said Eadie, would not have made any difference to the decision ultimately reached, or the basis on which it was reached.‘In reality, the claimant’s case is that a re-opening of consultation by reference to the reports would have given them the opportunity to reiterate arguments that they had already had the opportunity to make,’ said Eadie. ‘Neither the Otterburn nor the KPMG report had the slightest impact on the lord chancellor’s stated objective of consolidation,’ said Eadie. ‘The lord chancellor ultimately made a decision – which is not challenged on its merits – to adopt measures to encourage market consolidation.’At the end of the hearing Burnett said he hoped to have judgment ready ‘as soon as possible’ and ‘all being well’ by the end of the month.
SWITZERLAND: Three manufacturers have prequalified for a contract to supply a total of 194 electric-multiple units in a procurement process which is being run by Swiss Federal Railways and its local operating joint ventures Thurbo in Thurgau and RegionAlps in Valais.The shortlisted bidders announced on September 1 are Alstom, Siemens Mobility and Stadler.The procuring bodies are seeking a single-deck design which is already proven in use in Europe, rather than a new type. The bidders were required to demonstrate their economic performance, capacity and resources, quality management, sustainability and their compliance with legal requirements.The three manufacturers now have until mid-2021 to prepare their bids. The contract is expected to be awarded by 2022, with the first trains entering service from the December 2025 timetable change.The 194 EMUs would primarily replace life-expired vehicles, and the contract would include options for a further 316 units which could be exercised as required.